“These are substantial upgrades in our vaccines, in terms of their ability to prevent infection, to prevent transmission, certainly to prevent serious illness and death” -Dr Jha
I have though about N protein was a vaccine target, it doesn't look good to go at this protein, I know I have seen failed N targeted vaccines, just cant find the links. But this article shows unique properties of the N protein,
"We present here evidence that coronaviruses also possess VSR, which was identified as N protein that shares similar structural architecture and gRNA/subgenomic RNA (sgRNA) binding activity to enhance the viral transcription, replication, and assembly among coronaviruses."
So before they even suggest in open conversations, "our experts", about using any part of the N protein, they better do a deep dive!! IMO!! Peace
Hey Tim the quoted paragraph below is in your work twice. It's under the part, "The Plan All Along."
Good piece though, thank you❣️
“We do acknowledge that situations will likely arise where it is on longer ethically permissible and therefore no longer feasible to continue placebo controlled follow up in an ongoing trial, or to initiate a placebo controlled trial. In those situations, if widespread availability of a licensed Covid19 vaccine precludes use of the placebo comparator, then the licensed vaccine could be used as a comparator to evaluate relative vaccine efficacy of other vaccines, testing the confidence interval lower bound against a non-inferiority margin” -Doran Fink Oct 22, 2020 (src)"
I have though about N protein was a vaccine target, it doesn't look good to go at this protein, I know I have seen failed N targeted vaccines, just cant find the links. But this article shows unique properties of the N protein,
"The Nucleocapsid Protein of Coronaviruses Acts as a Viral Suppressor of RNA Silencing in Mammalian Cells" https://journals.asm.org/doi/10.1128/JVI.01331-15
"We present here evidence that coronaviruses also possess VSR, which was identified as N protein that shares similar structural architecture and gRNA/subgenomic RNA (sgRNA) binding activity to enhance the viral transcription, replication, and assembly among coronaviruses."
So before they even suggest in open conversations, "our experts", about using any part of the N protein, they better do a deep dive!! IMO!! Peace
Don't take the deathvax. Immaculate Heart of Mary pray for us.
Sacred Heart of Jesus have mercy on us.
Hey Tim the quoted paragraph below is in your work twice. It's under the part, "The Plan All Along."
Good piece though, thank you❣️
“We do acknowledge that situations will likely arise where it is on longer ethically permissible and therefore no longer feasible to continue placebo controlled follow up in an ongoing trial, or to initiate a placebo controlled trial. In those situations, if widespread availability of a licensed Covid19 vaccine precludes use of the placebo comparator, then the licensed vaccine could be used as a comparator to evaluate relative vaccine efficacy of other vaccines, testing the confidence interval lower bound against a non-inferiority margin” -Doran Fink Oct 22, 2020 (src)"
Thanks, good catch.