Chloroquine Devastates Male Rat Fertility: 4 Rat Studies Show Massively Deleterious Effects
Another Drug Pushed On Public Without Disclosure Of Risks - No Amnesty!
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Note: hydroxychloroquine is a very similar but slightly modified formulation of chloroquine
Chloroquine Crushes Male Rat Fertility: Dose Dependent Reduction In Number of Pups In Litter
In a study called ‘An investigation into the effects of chloroquine on fertility of male rats’ by Okanlawon et al, researchers gave Sprague-Dawley rats chloroquine and compared litter sizes by fathers’ treatment group against litter sizes of the no-chloroquine control rats.
“Females mated with treated males showed a dose dependent decrease in the number of litter per female rat… The results of the in-vitro study suggests that chloroquine has a direct toxic effect on sperm.”
Wistar Rat Fertility Study
Let’s next explore a study called ‘Effects of chloroquine on male fertility in Wistar rats’ by Vawda et al. (full report)
Researchers observed a large 53% reduction in the pups sired by the male rats who received Chloroquine:
“Chloroquine reduced litter size and increased the incidence of stillbirths and abnormal pups”
“The drug appears to be deleterious both at the testicular and epididymal levels”
“The reduction in the number of testicular cells in treated rats correlates with a reduction in testicular weight”
Rat Study Shows Massive Sperm Motility Drop In Rats Post Chloroquine
In a study called ‘Chloroquine reduces fertilizing capacity of epididyma sperm in rats’ by Adeeko et al. they performed fertility studies
“In the in-vitro studies, more than 80% of spermatozoa were immotile in all concentrations of chloroquine tested.”
“Chloroquine effected a dose-related reduction in fertility of the male rats as evidenced by a reduction in average number of foetuses of cohabited females, although the sperm count in the groups was not significantly different. This suggest that the drug does play an inhibitory role in sperm function”
Chloroquine Vs Male Albino Rat Fertility Study
In a paper called ‘Comparative Orchidotoxicity Study Between Chloroquine Phosphate and Hydroxychloroquine Sulfate on Adult Albino Rats’ by Elgndy et al
“Six-week administration of CQP [Chloroquine phosphate] revealed occurrence of severe detrimental effects on the reproductive system of adult rats. Therefore, much more attention should be paid to CQP drug as a possible cause of male contraceptive and infertility especially when prescribed for long period of time or used in high daily doses to treat various diseases in children and adult male individuals.”
if we account for the -38% drop in sperm count and a -58% decline in sperm motility, this corresponds with a change of the motile sperm count of 74% for the chloroquine treated rats vs the control!
PGP & CYP3A4
Since both chloroquine and hydroxychloroquine, like ivermectin, are PGP inhibitors and PGP substrates , each metabolized by the CYP2C8 and CYP3A4 enzymes, many of the concepts we have discussed previously regarding ivermectin toxicity are applicable to these drugs as well.
Here are articles with more information: