Poison Alert: Dangerous Methylene Blue Pushed In Latest Assault On Our Health

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Jun 18, 2023

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I came across a very troubling document on the FDA’s website concerning methylene blue: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/204630s000lbl.pdf

“Methylene blue inhibits CYP isozymes 1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5 in vitro. Possible time-dependent inhibition of CYP2C9, CYP2D6 and CYP3A4/5 (testosterone as substrate) was also observed in vitro.”

“In a two-year carcinogenicity study, rats were administered oral doses of methylene blue at 5, 25, or 50 mg/kg. Methylene blue caused pancreatic islet adenomas or carcinomas (combined) in male rats.”

“Methylene blue was genotoxic in gene mutation assays in bacteria (Ames test), and in an in vitro sister chromatid exchange test and an in vitro chromosomal aberration test in Chinese hamster ovary (CHO) cells.”

“Fertility studies with methylene blue have not been conducted. In vitro, methylene blue reduced motility of human sperm in a concentration dependent manner”

And death is listed as a posssible adverse reaction amidst a slew of other bad outcomes:

CYP3A4 & Pgp Inhibition

Another very troubling FDA document from the Center for Drug Evaluation and Research states that Methylene Blue is a Pgp & CYP450 3A4 inhibitor: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/204630Orig1s000ClinPharmR.pdf

The Cmax refers to the highest concentration of a drug achieved in the body after administration

The ki (inhibition constant) is a measure of how effectively a substance inhibits an enzyme's activity. In this context, it represents the inhibitory potency of methylene blue on the specific CYP450 enzyme being studied.

By calculating the ratio of Cmax to ki, researchers can assess the relative strength of inhibition by methylene blue on each CYP450 enzyme. The resulting R values provide a numerical measure of the extent of inhibition, with higher R values indicating stronger inhibition.

The statement mentions that the R values for methylene blue ranged from 4 to 60. This means that methylene blue exhibited varying degrees of inhibition on the CYP450 enzymes studied, with some enzymes being more strongly inhibited (higher R values) than others.

According to this source, Methylene Blue carries an IC50 (concentration required to inhibit 50%) for the crucial enzyme CYP450 3A4 of just 122ng/mL

In a paper called ‘In Vitro Assessment of Methylene Blue Hydrate as a Multiple CYP450 Inhibitor and a Mechanism-Based Inhibitor’ by Jeong et al.

“Drug-drug interactions (DDIs) remain an important issue in the drug discovery and development. Especially, cytochrome P450 (CYP450) inhibition and mechanism-based inhibition (MBI) might cause clinically significant DDIs”
“MBH [Methylene Blue] at a concentration of 10 µM showed more than 87% inhibition for six CYP450 enzymes, CYP1A2, 2C8, 2C9, 2C19, 2D6, and 3A4 (using two substrates). IC50 value for 1A2 was 0.63 µM, 2C8 was 2.66 µM, 2C9 was 1.46 µM, 2C19 was 0.33 µM, 2D6 was 1.67 µM, 3A4 using nifedipine as a substrate was 2.71 µM, and 3A4 using testosterone as a substrate was 1.01 µM, respectively. As a result, MBH showed moderate to potent inhibition (IC50 < 10 µM) in tested six CYP450 isoforms.”

So the measured IC50 for Methylene Blue on the CYP450 3A4 was 2.71 µM when using nifedipine as the substrate.

In a paper called ‘The Interactions of P-Glycoprotein with Antimalarial Drugs, Including Substrate Affinity, Inhibition and Regulation’ (full report)

“A positive efflux ratio was observed with methylene blue. It could be reduced by about 50% when co-incubated with PSC 833, which still left a significant efflux ratio associated with this drug, implying P-gp and others transporters are continuing to remove methylene blue from cells. Co-incubation with MK571 and PSC 833 created parity of directional transport suggesting that methylene blue is a joint substrate for both MRP2 as well as P-gp”

It is crucial to emphasize the following point: I have observed a significant promotion of Methylene Blue to individuals who are also being subjected to propaganda advocating the use of the neurotoxic ivermectin. Research indicates that combining these two drugs could amplify their adverse effects, as Ivermectin is a neurotoxic Pgp substrate that is metabolized by CYP450 3A4 meanwhile Methylene Blue is an inhibitor of both Pgp and CYP450 3A4. Additionally, there are many other compounds being promoted that possess inhibitory effects on Pgp or CYP450 3A4. It appears that selective information about these compounds is being emphasized while neglecting the significant concerns, leading people to overdose on medications.

Mutagenicity Of Methylene Blue

In a paper called “Mammalian genotoxicity assessment of methylene blue in plasma: implications for virus inactivation” by Wagner et al (full report)

“Methylene blue is mutagenic in cultured mammalian cells.”

Evidence Of Carcinogenic Activity

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr540.pdf

“Under the conditions of these 2-year gavage studies, there was some evidence of carcinogenic activity* of methylene blue trihydrate in male F344/N rats based on increased incidences of pancreatic islet cell adenoma and adenoma or carcinoma (combined).”

1 Month Study of Repeated Dosing Methylene Blue in Mice:

“None of the mice in the 500, 1,000, and 2,000 mg/kg groups survived to the end of the study. In the 250 mg/kg groups, two females died on days 16 and 18 and two males died on days 6 and 13.”

“Hypothermia and abnormal posture were observed in mice in the 500, 1,000, and 2,000 mg/kg groups. Dosed mice developed methemoglobinemia and a regenerative Heinz body anemia."

“Significant increases in spleen weights occurred in all surviving dosed groups of mice compared to vehicle controls.”

“Lesions in the spleen associated with methylene blue tri-hydrate administration included hematopoietic cell proliferation, pigmentation, and congestion. Liver lesions associated with methylene blue trihydrate administration included periportal degeneration, hematopoietic cell proliferation, and Kupffer cell pigmentation with eryth-rophagocytosis.”

“Forestomach lesions that were related to methylene blue trihydrate administration included focal ulcer, inflammation, and squamous hyperplasia.”

3 month study of repeated dosing Methylene Blue in mice:

“Dosed rats developed methemoglobinemia and a regenerative Heinz body anemia”

“Spleen lesions in dosed rats included hematopoietic cell proliferation, congestion, lymphoid depletion of the lymphoid follicles, and capsular fibrosis. The incidences of bone marrow hyperplasia were significantly increased in groups administered 50 mg/kg or greater.”

2 Year Study Of Continued Methylene Blue Dosing In Rats:

“Dosed male and female rats developed methemoglobinemia, and females developed a regenerative Heinz body anemia.”

“The incidences of pancreatic islet cell adenoma and adenoma or carcinoma (combined) were increased in all dosed groups of males, were significantly increased in 25 mg/kg males, and exceeded the historical range in controls (all routes). The incidence of pancreatic islet cell hyperplasia was significantly increased in the 50 mg/kg males.”

2 Year Study Of Continued Methylene Blue Dosing In Mice:

“Dosed mice developed methemoglobinemia and a regenerative Heinz body anemia.”

“The incidences of carcinoma and of adenoma or carcinoma (combined) of the small intestine occurred with a positive trend in males. The incidences of malignant lymphoma occurred with a positive trend in females, and the incidence in 25 mg/kg males exceeded the historical control range.”

Genotoxicity Studies:

“Methylene blue trihydrate was mutagenic in Salmonella typhimurium strains TA98 and TA100 with and without rat or hamster liver S9 activation enzymes”

“Mutagenicity was also observed in Escherichia coli strain WP2 urvA/pKM101 with and without rat liver S9.”

“In cytogenetic tests with cultured Chinese hamster ovary cells, methylene blue trihydrate induced sister chromatid exchanges and chromosomal aberrations with and without S9.”

“In the 3-month micronucleus tests, a dose-related increase in the percentage of reticulocytes among the total erythrocyte population was observed in both male and female mice.”

Many Methylene Blue Drug Interactions

Many of the Methylene Blue drug pushers fail to mention the many major adverse drug interactions when Methylene Blue is combined with other commonly used drugs. Drugs.com has a lengthy list of some of the known drug interactions of Methylene Blue:

https://www.drugs.com/drug-interactions/methylene-blue-index.html

Additional Quotations On Methylene Blue

In a paper called ‘Synergistic degradation of methylene blue by laser cavitation and activated carbon fiber’ by Tong et al:

“Methylene blue is widely used, but highly toxic and difficult to be degraded.”

In a paper called ‘Fundamentals and photocatalysis of methylene blue dye using various nanocatalytic assemblies- a critical review’ by Din et al.

“Methylene blue (MB) is a carcinogenic pollutant widely known for its hazardous impacts on humans and marine life”

Tim Truth

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